Projects - CJD




Prion Protein


Creutzfeldt-Jakob disease (CJD) is associated with critical proteins in the brain misfolding ie adopting a different 3-D shape. As a consequence the brain gradually fails to function. It is believed to be triggered by the presence of small quantities of Prion Protein which catalyse the misfolding. A molecule which binds to the prion protein might prevent it from interacting with and misfolding other proteins and has therapeutic potential to stop the progression of the disease.

Job times for this query are slightly longer than typical jobs giving more than typical numbers of hits.

query: 1QM3-Q3
% jobs complete: 100.000
molecules: 510,390,146
hits: 2,860,950
time: 619:262:16:57:19
Pictures   R Zahn et al, Proc Nat Acad Sci (2000) 97 p145   last updated: 12:00 on 21-JAN-06