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In the developed world, an understanding of how HIV is spread is reducing the rate of transmission, and the availability of drugs is limiting the progression to AIDS and improving the quality of life. Although therapies would be better if a cure was available, the situation is much better than in the third world. Here HIV is spreading at epidemic levels and many of the drugs are not available. In addition, some strains of HIV are developing which are resistant to the current generation of drugs.

The HIV project started in July 2003 and seeks out molecules that have the potential to inhibit the development of AIDS in a novel way. The essence of this approach relies of preventing the virus gaining entry to human cells.