Projects - Malaria

Protein

Description

Statistics

Dihydrofolate reductase

 

Dihydrofolate reductase (DHFR) has recently been suggested as a drug target for Malaria and other parasitic diseases including toxoplasmosis and cryptosporidiosis - see DDT (2005) 10.2 p121. There have also been suggestions that DHFR drug resistance may be a problem. DHFR has been considered as a cancer target by some scientists.

This query has been replaced by 1j3i-q2.



 
query: 1J3I-Q1
% jobs complete: 0.020
molecules: 9,793
hits: 357
time: 0:002:09:31:14
Pictures   J Yuvaniyama et al Nat Struct Biol (2003) 10 p357   last updated: 06:07 on 30-JAN-05

Hgprtase

 

Hypoxanthine-Guanine Phosphoribosyltransferase (Hgprtase) is important as a source of purine to Plasmodium falciparum (the parasite which causes Malaria). This is because the parasite is unable to make its own purine. It has been suggested that inhibiting this enzyme may be therapeutically valuable. This query is based on a different crystal structure to 1d6n-q1.

In test jobs, this query gave more hits than usual with variable times.



 
query: 1BZY-Q1
% jobs complete: 100.000
molecules: 39,643,949
hits: 298,804
time: 5:122:19:52:17
Pictures   G K Balendiran et al, Protein Sci (1999) 8.5 p1023   last updated: 12:07 on 23-SEP-05

Purine Phosphoribosyl transferase

 

Plasmodium falciparum, the parasite associated with Malaria, has to salvage purine from human cells because it cannot make it. Phosphoribosyl transferase (PRTase) does so and is a recognised anti-malaria drug target.

Job times for this query vary but most are faster than typical jobs giving typical numbers of hits.



 
query: 1CJB-Q2
% jobs complete: 100.000
molecules: 39,621,227
hits: 242,128
time: 4:174:16:20:36
Pictures   W Shi et al Biochemistry (1999) 38 p 9872   last updated: 12:10 on 02-AUG-05

Rab6

 

Rab6 is a RAS-like GTP binding protein which plays an important role in Plasmodium falciparum (the parasite that causes Malaria). A selective inhibitor for this GTP binding protein might have therapeutic potential for Malaria.

This query gave higher than average number of hits and longer job times for some sample jobs.



 
query: 1D5C-Q1
% jobs complete: 100.000
molecules: 39,627,600
hits: 710,595
time: 22:264:10:47:19
Pictures   D Chattopadhyay et al Acta Cryst D (2000) 56.8 p937-44.   last updated: 12:13 on 24-JUN-05

Hgprtase

 

Hypoxanthine-Guanine Phosphoribosyltransferase (Hgprtase) is important as a source of purine to Plasmodium falciparum (the parasite which causes Malaria). This is because the parasite is unable to make its own purine. It has been suggested that inhibiting this enzyme may be therapeutically valuable.

In test jobs, this query gave more hits than usual taking more time than typical jobs.



 
query: 1D6N-Q1
% jobs complete: 100.000
molecules: 39,627,699
hits: 601,580
time: 16:044:02:33:25
Pictures   G K Balendiran et al, Protein Sci (1999) 8.5 p1023   last updated: 00:09 on 22-JUL-05

Dihydrofolate reductase

 

Dihydrofolate reductase (DHFR) has recently been suggested as a drug target for Malaria and other parasitic diseases including toxoplasmosis and cryptosporidiosis - see DDT (2005) 10.2 p121. There have also been suggestions that DHFR drug resistance may be a problem. DHFR has been considered as a cancer target by some scientists.

This query has typical job times with average numbers of hits it replaces 1j3i-q1 which would have ran longer and given more hits than appropriate.



 
query: 1J3I-Q2
% jobs complete: 100.000
molecules: 39,627,514
hits: 97,458
time: 4:325:21:00:07
Pictures   J Yuvaniyama et al Nat Struct Biol (2003) 10 p357   last updated: 18:15 on 03-APR-05

Plasmepsin 2

 

Plasmodium falciparum (the parasite which causes Malaria) invades erythrocyte cells and consumes the host hemoglobin. Plasmepsin 2 plays a key role digesting the protein and has been recognised as a novel target for anti-malaria drugs. Inhibition of hemoglobin degradation lead to toxic concentrations and parasite death in culture.



 
query: 1LEE-Q1
% jobs complete: 100.000
molecules: 39,864,900
hits: 991,825
time: 41:050:02:30:01
Pictures   O A Asojo et al Acta Cryst (2002) d58 p2001   last updated: 12:22 on 07-DEC-04

Plasmepsin 2

 

Plasmodium falciparum (the parasite which causes Malaria) invades erythrocyte cells and consumes the host hemoglobin. Plasmepsin 2 plays a key role digesting the protein and has been recognised as a novel target for anti-malaria drugs. Inhibition of hemoglobin degradation lead to toxic concentrations and parasite death in culture. This query is based on a different crystal structure to 1lee-q1.

We expect jobs for this query to give typical numbers of hits in less time than typical jobs.



 
query: 1LF2-Q1
% jobs complete: 100.000
molecules: 39,627,561
hits: 202,816
time: 4:183:10:13:12
Pictures   O A Asojo et al Acta Cryst (2002) d58 p2001   last updated: 06:13 on 26-JUL-05

Plasmepsin IV

 

Plasmodium falciparum (the parasite which causes Malaria) invades erythrocyte cells and consumes the host hemoglobin. Plasmepsin plays a key role digesting the protein and has been recognised as a novel target for anti-malaria drugs. Inhibition of hemoglobin degradation lead to toxic concentrations and parasite death in culture. This query is based on a different crystal structures to 1lf2-q1 and 1lee-q1.

We expect jobs for this query to give more than typical numbers of hits in average times.



 
query: 1LS5-Q2
% jobs complete: 100.000
molecules: 510,442,169
hits: 3,269,913
time: 121:173:12:21:41
Pictures   O A Asojo et al Acta Cryst (2002) d58 p2001   last updated: 06:00 on 25-JAN-06

Trisephosphate isomerase

 

This enzyme plays a crucial role in the energy cycle of Plasmodium falciparum (the parasite which causes Malaria) and certain other parasitic diseases such as Chagas Disease. Both of these diseases are rare in the Western world.

This query gave average number of hits and below average job times for some sample jobs.



 
query: 1M7P-Q1
% jobs complete: 100.000
molecules: 39,627,744
hits: 224,854
time: 4:208:03:03:25
Pictures   S Parthasarathy et al, Acta Cryst D (2002) 58.12 p1992-2000   last updated: 18:17 on 29-MAR-05

Enoyl Reductase (ENR)

 

In Plasmodium falciparum (the parasite which causes Malaria), Enoyl Reductase (ENR) plays a critical role creating long chain molecules known as fatty acids which are used in the synthesis of cell wall mycolic acids. Effective inhibition of this enzyme has been demonstrated to have therapeutic potential in the treatment of Malaria.

Inhibiting Enoyl Reductase in Mycobacterium tuberculosis would also be effective against drug resistant strains of TB.



 
query: 1P45-Q1
% jobs complete: 100.000
molecules: 510,653,562
hits: 1,001,724
time: 56:029:17:11:42
Pictures   M R Kuo et al J Biol Chem (2003) 278.23 p20851-20859   last updated: 00:00 on 24-JAN-06

Camodulin

 

Plasmodium falciparum, the parasite associated with Malaria, has an obligate calcium requirement for normal growth and invasion of host erythrocytes. It has been shown that inhibiting Camodulin has therapeutic potential in the treatment of Malaria. Selectivity for the parasite and side effects may still be issues. This is an alternative query to 1xa5-q2 based on a different crystal structure.

Job times for this query are typical jobs giving typical numbers of hits.



 
query: 1QIW-Q1
% jobs complete: 100.000
molecules: 39,627,475
hits: 229,351
time: 6:112:04:56:30
Pictures   V Harmat et al J Mol Biol (2000) 297 p747   last updated: 12:14 on 13-JUN-05

Peptide deformylase

 

Plasmodium falciparum is the parasite associated with Malaria. Peptide deformylase is a new antibiotic target which may also be a useful target for new Malaria drugs.

Job times for this query do vary but usually take a few hours on a typical PC often giving variable numbers of hits.



 
query: 1RL4-Q1
% jobs complete: 100.000
molecules: 39,627,231
hits: 328,178
time: 2:324:21:57:09
Pictures   M A Robien et al Protein Sci (2004) 13 p1155   last updated: 06:07 on 30-MAR-05

Camodulin

 

Plasmodium falciparum, the parasite associated with Malaria, has an obligate calcium requirement for normal growth and invasion of host erythrocytes. It has been shown that inhibiting Camodulin has therapeutic potential in the treatment of Malaria. Selectivity for the parasite and side effects may still be issues.

Job times for this query are slightly shorter than typical jobs giving typical numbers of hits.



 
query: 1XA5-Q2
% jobs complete: 100.000
molecules: 39,627,546
hits: 103,460
time: 2:061:07:28:40
Pictures   L W Scheibel et al Proc Nat Acad Sci (1987) 84.20 p7310-4   last updated: 12:12 on 03-JUN-05