Projects - Multiple Sclerosis

Protein

Description

Statistics

Poly (ADP-Ribose) Polymerase (PARP)

 

PARP is believed to play a role in in neurodegenerative diseases. The details are complex and not fully understood. One major component of inflammatory neuronal damage is the transformation of microglia cells into activated immunoeffector cells and their migration towards the sites of injury, where they produce large amounts of toxic cytokines and oxygen radicals. PARP also regulates the production of certain proteins.

PARP also has a potential therapeutic role in cancer treatment. It facilitates the repair of DNA strand breaks and its inhibition may make radiotherapy and chemotherapy more effective when resistance occurs.

We expect job times of about 8-20 hours and above average hit rates.



 
query: 1EFY-Q1
% jobs complete: 100.000
molecules: 78,706,360
hits: 666,186
time: 86:320:23:29:31
Pictures   A W White et al J Med Chem (2000) 43 p4084   last updated: 18:15 on 09-DEC-04

Interleukin-12

 

Interleukin-12 (IL-12) belongs to the cytokine class of proteins and is crucial for the generation of immunity to intracellular pathogens. It is known to stimulate production and enhance the activity of natural killer cells and T cells, and to induce production of interferon. It is important in preventing infection by intracelluar bacteria and parasites. IL-12 also contributes to various immunopathological conditions, so understanding its role may lead to new therapies for rheumatoid arthritis, multiple sclerosis and other autoimmune diseases.



 
query: 1F42-Q1
% jobs complete: 100.000
molecules: 78,749,862
hits: 68,152
time: 8:222:01:11:04
Pictures   C Yoon et al, EMBO Journal (2000) 19 p3530   last updated: 18:49 on 23-SEP-03

Human Interleukin-12B

 

Interleukin-12B (IL-12B) belongs to the cytokine class of proteins and is crucial for the generation of immunity to intracellular pathogens. It is known to stimulate production and enhance the activity of natural killer cells and T cells, and to induce production of interferon. It is important in preventing infection by intracelluar bacteria and parasites. IL-12B also contributes to various immunopathological conditions, so understanding its role may lead to new therapies for rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. This query differs from 1f42-q1 because we are targetting a site on the beta subunit.



 
query: 1F45-Q2
% jobs complete: 100.000
molecules: 78,707,679
hits: 43,236
time: 77:315:23:30:13
Pictures   C Yoon, S C Johnston, J Tang, M Stahl, J F Tobin and W S Somers Embo Journal 19 p3530 (2000)   last updated: 18:36 on 30-SEP-03

Human Interleukin-12B

 

Interleukin-12B (IL-12B) belongs to the cytokine class of proteins and is crucial for the generation of immunity to intracellular pathogens. It is known to stimulate production and enhance the activity of natural killer cells and T cells, and to induce production of interferon. It is important in preventing infection by intracelluar bacteria and parasites. IL-12B also contributes to various immunopathological conditions, so understanding its role may lead to new therapies for rheumatoid arthritis, multiple sclerosis and other autoimmune diseases. This query targets a variant of the site used in 1f42-q2 .



 
query: 1F45-Q3
% jobs complete: 100.000
molecules: 510,445,031
hits: 2,153,821
time: 228:343:17:12:10
Pictures   C Yoon, S C Johnston, J Tang, M Stahl, J F Tobin and W S Somers Embo Journal 19 p3530 (2000)   last updated: 18:00 on 25-JAN-06

Myelin Oligodendrocyte Glycoprotein

 

Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and nerve axon loss. The immune response is responsible for the degradation of the protective myelin sheath around the spinal cord. This involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG) located at the surface of CNS myelin. This is the first of a short series of queries where we seek small molecules which might inhibit the immune responsible which would halt the progress of the disease.

Test jobs for this query gave relatively few hits and took less time than average jobs.



 
query: 1PKQ-Q1
% jobs complete: 100.000
molecules: 39,651,665
hits: 4,641
time: 3:230:02:25:25
Pictures   C Breithaupt et al Proc Nat Acad Sci (2003) 100 p9446   last updated: 18:07 on 19-SEP-05

Myelin Oligodendrocyte Glycoprotein

 

Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and nerve axon loss. The immune response is responsible for the degradation of the protective myelin sheath around the spinal cord. This involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG) located at the surface of CNS myelin. This is the second of a short series of queries where we seek small molecules which might inhibit the immune responsible which would halt the progress of the disease. The series target different sites of the same protein.

Test jobs for this query took longer than typical jobs giving average numbers of hits.



 
query: 1PKQ-Q3
% jobs complete: 100.000
molecules: 39,652,493
hits: 445,810
time: 22:190:21:10:45
Pictures   C Breithaupt et al Proc Nat Acad Sci (2003) 100 p9446   last updated: 18:08 on 20-SEP-05

Myelin Oligodendrocyte Glycoprotein

 

Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and nerve axon loss. The immune response is responsible for the degradation of the protective myelin sheath around the spinal cord. This involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG) located at the surface of CNS myelin. This is the second of a short series of queries where we seek small molecules which might inhibit the immune responsible which would halt the progress of the disease. The series target different sites of the same protein.

Test jobs for this query took less time than typical jobs giving few hits.



 
query: 1PKQ-Q4
% jobs complete: 100.000
molecules: 39,653,887
hits: 5,733
time: 2:254:13:16:38
Pictures   C Breithaupt et al Proc Nat Acad Sci (2003) 100 p9446   last updated: 18:06 on 09-SEP-05

Tumor Necrosis Factor (TNF) Receptor P55

 

Tumor Necrosis Factor (also known as cachetin) is an inflammatory mediator that is relevant to several autoimmune diseases and bacterial infection. In this query we are targetting TNF Receptor 1 (also known as p55) which is thought to be associated with the inflammatory response. Suppression of such inflammatory responses would be expected to benefit suffers of Multiple Sclerosis. TNF's name originates from the observation over 100 years ago causing beneficial inflammatory effects resulting in tumour cell death in terminally ill cancer patients.



 
query: 1TNR-Q2
% jobs complete: 100.000
molecules: 39,878,434
hits: 7,229
time: 7:078:06:55:25
Pictures   D W Banner et al Cell (1993) 73 p 431   last updated: 12:23 on 09-FEB-04